Human Genomics prove the existence of Chronic Fatigue Syndrome
> Any general comments regarding this and the
> statistical reliability of
> microarray sampling methodology in general?
>
> LA Times:
> "Chronic fatigue syndrome, often dismissed as the
> imaginings of depressed
> and whiny people, is caused by genetic mutations
> that impair the central
> nervous system's ability to adapt to stressful
> situations, according to a
> major new study by the Centers for Disease Control
> and Prevention."
> http://www.latimes.com/news/science/la-sci-fatigue21apr21,0,6152443.story?coll=la-home-headlines
>
> Pharmacogenomics:
> http://www.futuremedicine.com/doi/abs/10.2217/14622416.7.3.387
>
William C. Reeves, the project coordinator as quoted in washington post (http://www.washingtonpost.com/wp-dyn/content/article/2006/04/20/AR2006042001869.html):
"...the growing evidence of genetic links should put to rest the idea that the syndrome is a made-up diagnosis for "a bunch of hysterical, upper-class white women."
There are several biomechanical genomics study reports on chronic fatigue syndrome in the referenced issue of Pharmacogenomics, which is all about the use of human genetics data in medicine. There is an editorial, two review articles, and a perspective about the chronic fatique genetic studies that, I think, explain these studies in the proper context. At the same time, I think, they reflect the zeal genetics industry leaders have in progressing the application of this science.(http://www.futuremedicine.com/toc/pgs/7/3),
Also from the Washington Post article:
"The new study involved 227 residents of Wichita, Kan., who spent two full days in a hospital undergoing a series of blood tests, hormone studies, psychological exams and sleep studies.
"About one-quarter of them met the formal definition of chronic fatigue syndrome. A similar number proportion had chronic fatigue but did not rank as having the full-blown syndrome -- in many cases because their fatigue was not severe enough. A third group met all of the requirements of the syndrome but also had melancholic depression, which does not fit the current diagnostic guidelines for chronic fatigue syndrome. And a fourth group, for comparison purposes, was healthy.
"The CDC, which invested about $2 million in the testing, then made blood-test results and other data available to researchers, who performed a wide variety of analyses."
The CDC flipped the $2 million bill for this study.
> statistical reliability of
> microarray sampling methodology in general?
>
> LA Times:
> "Chronic fatigue syndrome, often dismissed as the
> imaginings of depressed
> and whiny people, is caused by genetic mutations
> that impair the central
> nervous system's ability to adapt to stressful
> situations, according to a
> major new study by the Centers for Disease Control
> and Prevention."
> http://www.latimes.com/news/science/la-sci-fatigue21apr21,0,6152443.story?coll=la-home-headlines
>
> Pharmacogenomics:
> http://www.futuremedicine.com/doi/abs/10.2217/14622416.7.3.387
>
William C. Reeves, the project coordinator as quoted in washington post (http://www.washingtonpost.com/wp-dyn/content/article/2006/04/20/AR2006042001869.html):
"...the growing evidence of genetic links should put to rest the idea that the syndrome is a made-up diagnosis for "a bunch of hysterical, upper-class white women."
There are several biomechanical genomics study reports on chronic fatigue syndrome in the referenced issue of Pharmacogenomics, which is all about the use of human genetics data in medicine. There is an editorial, two review articles, and a perspective about the chronic fatique genetic studies that, I think, explain these studies in the proper context. At the same time, I think, they reflect the zeal genetics industry leaders have in progressing the application of this science.(http://www.futuremedicine.com/toc/pgs/7/3),
Also from the Washington Post article:
"The new study involved 227 residents of Wichita, Kan., who spent two full days in a hospital undergoing a series of blood tests, hormone studies, psychological exams and sleep studies.
"About one-quarter of them met the formal definition of chronic fatigue syndrome. A similar number proportion had chronic fatigue but did not rank as having the full-blown syndrome -- in many cases because their fatigue was not severe enough. A third group met all of the requirements of the syndrome but also had melancholic depression, which does not fit the current diagnostic guidelines for chronic fatigue syndrome. And a fourth group, for comparison purposes, was healthy.
"The CDC, which invested about $2 million in the testing, then made blood-test results and other data available to researchers, who performed a wide variety of analyses."
The CDC flipped the $2 million bill for this study.
posted by nawledge at
8:44 PM
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